A mysterious event involving a strange artifact throws the world into tumoil. All of them men have been vaporized, while the women are transformed. Some become monster girls with an insatiable desire to either murder, devour or violate anyone unfortunate to be in the same vicinity as them. Others turn into futanari, who have forsaken their moral compass to satiate their unending lust. Then there are those who have gained mysterious powers. What awaits them in this cruel, savage world?