Araki Ryota, a 16-year-old boy, is involuntarily drawn into an experiment called D.R.E.A.M. There, participants can remember and control their actions in dreams with the help of a pill provided by DreamLink Corp and the company promises the participants/dreamers to grant their wishes if they take part in the experiment.

Inside the dream, Araki soon realizes that the experiment is a deadly game where participants must face life-or-death trials.The senses are shared with their real bodies so pain inflicted in dreams can be transmitted to their real bodies,putting their lives at risk.The company promises to grant the wish of the sole survivor who passes all the trials and survives.

Araki must find a way to survive, uncover the real motive behind the experiment,and escape the twisted reality within dreams where one's mankind and humanity are tested in a world where people deceive and betray,and allies becomes their ultimate foes.