Mitch Calvert is 29 years old, an independent wrestler, and a goddamn mess. After suffering an injury during a match and being put on the shelf, he gets dumped by his boyfriend and is forced to yet again pick up the pieces of his life. He struggles with his self worth, combats addiction and trauma, and begrudgingly falls in love with his new roommate that he definitely has no chance with.

But what can he do? He can either take life's beatdown without putting up any resistance, or grab a steel chair and start swinging back.

Interpersonal Chemistry features a cast that's made up of queers, misfits, and wrestlers (sometimes all three) and takes place in the year 2018 in the fictional city of Monument, Massachusetts. It’s rated M, intended for mature audiences only due to sensitive subject matters such as: mental illness, addiction, trauma, violence (typical of the setting), and vulgar language.